Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection.

ABSTRACT: Septins are evolutionarily conserved GTP-binding proteins known for their roles in cell division and host defence against Shigella infection. Although septin group members are viewed to function as hetero-oligomeric complexes, the role of individual septins within these complexes or in isolation is poorly understood. Decades of work using mouse models has shown that some septins (including SEPT7) are essential for animal development, while others (including SEPT6) are dispensable, suggesting that some septins may compensate for the absence of others. The zebrafish genome encodes 19 septin genes, representing the full complement of septin groups described in mice and humans. In this report, we characterise null mutants for zebrafish Sept6 (a member of the SEPT6 group) and Sept15 (a member o

SUBMITTER: Torraca V 

PROVIDER: S-EPMC10952258 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature