Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes.

ABSTRACT: Platinum(IV) prodrugs are highly interesting alternatives to platinum(II) anticancer therapeutics due to their increased tumor selectivity and reduced side effects. In contrast to the established theory, we recently observed that the equatorial ligand(s) of e.g. oxaliplatin(IV) complexes can be hydrolyzed with formation of [(DACH)Pt(OH_eq )₂ (OAc_ax )₂ ]. In the work presented here, we investigated the reactivity and synthetic usability of this complex to be exploited as a precursor for the development of novel platinum(IV) complexes, not able to be synthesized by conventional protocols. Indeed, we could substitute the equatorial hydroxido ligand(s) e.g. by one or two monodentate biotin ligands (which would be oxidized under standard methods). The

SUBMITTER: Kastner A 

PROVIDER: S-EPMC10952260 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature