MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy.

ABSTRACT:

Objective

Epilepsy surgery fails to achieve seizure freedom in 30%-40% of cases. It is not fully understood why some surgeries are unsuccessful. By comparing interictal magnetoencephalography (MEG) band power from patient data to normative maps, which describe healthy spatial and population variability, we identify patient-specific abnormalities relating to surgical failure. We propose three mechanisms contributing to poor surgical outcome: (1) not resecting the epileptogenic abnormalities (mislocalization), (2) failing to remove all epileptogenic abnormalities (partial resection), and (3) insufficiently impacting the overall cortical abnormality. Herein we develop markers of these mechanisms, validating them against patient outcomes.

Methods

Resting-state MEG recordings wer

SUBMITTER: Owen TW 

PROVIDER: S-EPMC10952279 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature