Photocatalytic Dehalogenative Deuteration of Halides over a Robust Metal-Organic Framework.

ABSTRACT: Deuterium labelling of organic compounds is an important process in chemistry. We report the first example of photocatalytic dehalogenative deuteration of both arylhalides and alkylhalides (40 substrates) over a metal-organic framework, MFM-300(Cr), using CD₃ CN as the deuterium source at room temperature. MFM-300(Cr) catalyses high deuterium incorporation and shows excellent tolerance to various functional groups. Synchrotron X-ray powder diffraction reveals the activation of halogenated substrates via confined binding within MFM-300(Cr). In situ electron paramagnetic resonance spectroscopy confirms the formation of carbon-based radicals as intermediates and reveals the reaction pathway. This protocol removes the use of precious-metal catalysts from state-of-the-art processes b

SUBMITTER: Luo T 

PROVIDER: S-EPMC10952292 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature