Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep.

ABSTRACT: Maternal magnesium sulphate (MgSO₄ ) treatment is widely recommended before preterm birth for neuroprotection. However, this is controversial because there is limited evidence that MgSO₄ provides long-term neuroprotection. Preterm fetal sheep (104 days gestation; term is 147 days) were assigned randomly to receive sham occlusion with saline infusion (n = 6) or i.v. infusion with MgSO₄ (n = 7) or vehicle (saline, n = 6) from 24 h before hypoxia-ischaemia induced by umbilical cord occlusion until 24 h after occlusion. Sheep were killed after 21 days of recovery, for fetal brain histology. Functionally, MgSO₄ did not improve long-term EEG recovery. Histologically, in the premotor cortex and striatum, MgSO₄ infusion attenuated post-occlusi

SUBMITTER: Galinsky R 

PROVIDER: S-EPMC10952359 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature