Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders.

ABSTRACT: Human developmental disorders encompass a wide range of debilitating physical conditions and intellectual disabilities. Perturbation of protein kinase signalling underlies the development of some of these disorders. For example, disrupted SRPK signalling is associated with intellectual disabilities, and the gene dosage of DYRKs can dictate the pathology of disorders including Down's syndrome. Here, we review the emerging roles of the CMGC kinase families SRPK, CLK, DYRK, and sub-family HIPK during embryonic development and in developmental disorders. In particular, SRPK, CLK, and DYRK kinase families have key roles in developmental signalling and stem cell regulation, and can co-ordinate neuronal development and function. Genetic studies in model organisms reveal critical phenotypes includ

SUBMITTER: Hogg EKJ 

PROVIDER: S-EPMC10952393 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature