Exposure to weak opioids and risk of gastrointestinal tract cancers: A series of nested case-control studies.

ABSTRACT:

Aims

There is evidence gastrointestinal (GI) motility may play a role in the development of GI cancers. Weak opioids (codeine and dihydrocodeine) decrease GI motility, but their effect on GI cancer risk has not been assessed. We aim to assess the association between weak opioids and cancers of the GI tract.

Methods

A series of nested case-control studies was conducted using Scottish general practice records from the Primary Care Clinical Informatics Unit Research database. Oesophageal (n = 2432), gastric (n = 1443) and colorectal cancer (n = 8750) cases, diagnosed between 1999 and 2011, were identified and matched with up to five controls. Weak opioid use was identified from prescribing records. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using condi

SUBMITTER: Houston MG 

PROVIDER: S-EPMC10952439 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature