Inhibiting CSF1R alleviates cerebrovascular white matter disease and cognitive impairment.

ABSTRACT: White matter abnormalities, related to poor cerebral perfusion, are a core feature of small vessel cerebrovascular disease, and critical determinants of vascular cognitive impairment and dementia. Despite this importance there is a lack of treatment options. Proliferation of microglia producing an expanded, reactive population and associated neuroinflammatory alterations have been implicated in the onset and progression of cerebrovascular white matter disease, in patients and in animal models, suggesting that targeting microglial proliferation may exert protection. Colony-stimulating factor-1 receptor (CSF1R) is a key regulator of microglial proliferation. We found that the expression of CSF1R/Csf1r and other markers indicative of increased microglial abundance are significantly elevated i

SUBMITTER: Askew KE 

PROVIDER: S-EPMC10952452 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature