A temperature-controlled cooling system for accurate quantitative post-mortem MRI.

ABSTRACT:

Purpose

To develop a temperature-controlled cooling system to facilitate accurate quantitative post-mortem MRI and enable scanning of unfixed tissue.

Methods

A water cooling system was built and integrated with a 7T scanner to minimize temperature drift during MRI scans. The system was optimized for operational convenience and rapid deployment to ensure efficient workflow, which is critical for scanning unfixed post-mortem samples. The performance of the system was evaluated using a 7-h diffusion MRI protocol at 7T with a porcine tissue sample. Quantitative T₁ , T₂ , and ADC maps were interspersed with the diffusion scans at seven different time points to investigate the temperature dependence of MRI tissue parameters. The impact of temperature changes

SUBMITTER: Rieger SW 

PROVIDER: S-EPMC10952464 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature