Platelet transfusions and predictors of bleeding in patients with myelodysplastic syndromes.

ABSTRACT:

Objectives

This study aimed to describe the burden of thrombocytopenia, supportive care practices, bleeding complications and predictors of bleeding in MDS patients within a large Australian hospital network, to better understand the use and effectiveness of platelet transfusions in MDS.

Methods

A retrospective cohort study of patients aged ≥18 years with MDS, chronic myelomonocytic leukaemia or MDS/myeloproliferative overlap neoplasm admitted from 2016 to 2018 was conducted. Data were obtained from hospital medical records.

Results

One hundred seventy-nine patients (median age 78 years, 61.5% male) were identified. The median platelet count at first admission was 90 × 10⁹ /L. Twenty-eight (15.6%) patients had severe thrombocytopenia (platelet count <20 × 1

SUBMITTER: Mo A 

PROVIDER: S-EPMC10952506 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature