Myeloperoxidase creates a permissive microenvironmental niche for the progression of multiple myeloma.

ABSTRACT: Expression of myeloperoxidase (MPO), a key inflammatory enzyme restricted to myeloid cells, is negatively associated with the development of solid tumours. Activated myeloid cell populations are increased in multiple myeloma (MM); however, the functional consequences of myeloid-derived MPO within the myeloma microenvironment are unknown. Here, the role of MPO in MM pathogenesis was investigated, and the capacity for pharmacological inhibition of MPO to impede MM progression was evaluated. In the 5TGM1-KaLwRij mouse model of myeloma, the early stages of tumour development were associated with an increase in CD11b⁺ myeloid cell populations and an increase in Mpo expression within the bone marrow (BM). Interestingly, MM tumour cell homing was increased towards sites of elevated mye

SUBMITTER: Williams CMD 

PROVIDER: S-EPMC10952523 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature