Cannabidiol does not attenuate acute delta-9-tetrahydrocannabinol-induced attentional bias in healthy volunteers: A randomised, double-blind, cross-over study.

ABSTRACT:

Aims

To test how attentional bias and explicit liking are influenced by delta-9-tetrahydrocannabinol (THC) and whether these effects are moderated by cannabidiol (CBD).

Design

Double-blind, randomised, within-subjects cross-over study.

Setting

NIHR Wellcome Trust Clinical Research Facility at King's College Hospital, London, United Kingdom.

Participants/cases

Forty-six infrequent cannabis users (cannabis use <1 per week).

Intervention(s)

Across four sessions, participants inhaled vaporised cannabis containing 10 mg of THC and either 0 mg (0:1 CBD:THC), 10 mg (1:1), 20 mg (2:1) or 30 mg (3:1) of CBD, administered in a randomised order and counter-balanced across participants (a total of 24 order groups).

Measurements

Participants completed two task

SUBMITTER: Oliver D 

PROVIDER: S-EPMC10952555 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature