Survival and division fate programs are preserved but retuned during the naive to memory CD8⁺ T-cell transition.

ABSTRACT: Memory T cells are generated from naïve precursors undergoing proliferation during the initial immune response. Both naïve and memory T cells are maintained in a resting, quiescent state and respond to activation with a controlled proliferative burst and differentiation into effector cells. This similarity in the maintenance and response dynamics points to the preservation of key cellular fate programs; however, whether memory T cells have acquired intrinsic changes in these programs that may contribute to the enhanced immune protection in a recall response is not fully understood. Here we used a quantitative model-based analysis of proliferation and survival kinetics of in vitro-stimulated murine naïve and memory CD8⁺ T cells in response to homeostatic and activating signals to

SUBMITTER: Heinzel S 

PROVIDER: S-EPMC10952575 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature