Adaptation of a population pharmacokinetic model to inform tacrolimus therapy in heart transplant recipients.

ABSTRACT:

Aim

Existing tacrolimus population pharmacokinetic models are unsuitable for guiding tacrolimus dosing in heart transplant recipients. This study aimed to develop and evaluate a population pharmacokinetic model for tacrolimus in heart transplant recipients that considers the tacrolimus-azole antifungal interaction.

Methods

Data from heart transplant recipients (n = 87) administered the oral immediate-release formulation of tacrolimus (Prograf®) were collected. Routine drug monitoring data, principally trough concentrations, were used for model building (n = 1099). A published tacrolimus model was used to inform the estimation of K_a , V₂ /F, Q/F and V₃ /F. The effect of concomitant azole antifungal use on tacrolimus CL/F was quantified. Fat-fr

SUBMITTER: Kirubakaran R 

PROVIDER: S-EPMC10952588 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature