Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes.

ABSTRACT: Genetic variation is the major mechanism behind adaptation and evolutionary change. As most proteins operate through interactions with other proteins, changes in protein complex composition and subunit sequence provide potentially new functions. Comparative genomics can reveal expansions, losses and sequence divergence within protein-coding genes, but in silico analysis cannot detect subunit substitutions or replacements of entire protein complexes. Insights into these fundamental evolutionary processes require broad and extensive comparative analyses, from both in silico and experimental evidence. Here, we combine data from both approaches and consider the gamut of possible protein complex compositional changes that arise during evolution, citing examples of complete conservation to parti

SUBMITTER: Prokopchuk G 

PROVIDER: S-EPMC10952624 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature