The effect of aspirin and eicosapentaenoic acid on urinary biomarkers of prostaglandin E₂ synthesis and platelet activation in participants of the seAFOod polyp prevention trial.

ABSTRACT: Urinary prostaglandin (PG) E metabolite (PGE-M) and 11-dehydro (d)-thromboxane (TX) B₂ are biomarkers of cyclooxygenase-dependent prostanoid synthesis. We investigated (1) the effect of aspirin 300 mg daily and eicosapentaenoic acid (EPA) 2000 mg daily, alone and in combination, on urinary biomarker levels and, (2) whether urinary biomarker levels predicted colorectal polyp risk, during participation in the seAFOod polyp prevention trial. Urinary PGE-M and 11-d-TXB₂ were measured by liquid chromatography-tandem mass spectrometry. The relationship between urinary biomarker levels and colorectal polyp outcomes was investigated using negative binomial (polyp number) and logistic (% with one or more polyps) regression models. Despite wide temporal variability in PGE-M and

SUBMITTER: Sun G 

PROVIDER: S-EPMC10952676 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature