Feeding signals inhibit fluid-satiation signals in the mouse lateral parabrachial nucleus to increase intake of highly palatable, caloric solutions.

ABSTRACT: Chemogenetic activation of oxytocin receptor-expressing neurons in the parabrachial nucleus (Oxtr^PBN neurons) acts as a satiation signal for water. In this research, we investigated the effect of activating Oxtr^PBN neurons on satiation for different types of fluids. Chemogenetic activation of Oxtr^PBN neurons in male and female transgenic Oxtr^Cre mice robustly suppressed the rapid, initial (15-min) intake of several solutions after dehydration: water, sucrose, ethanol and saccharin, but only slightly decreased intake of Ensure®, a highly caloric solution (1 kcal/mL; containing 3.72 g protein, 3.27 g fat, 13.42 g carbohydrates, and 1.01 g dietary fibre per 100 mL). Oxtr^PBN neuron activation also suppressed cumulative, longer-term (2-h) i

SUBMITTER: Aitken CM 

PROVIDER: S-EPMC10952698 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature