Changes in cellular Ca²⁺ and Na⁺ regulation during the progression towards heart failure.

ABSTRACT: In adapting to disease and loss of tissue, the heart shows great phenotypic plasticity that involves changes to its structure, composition and electrophysiology. Together with parallel whole body cardiovascular adaptations, the initial decline in cardiac function resulting from the insult is compensated. However, in the long term, the heart muscle begins to fail and patients with this condition have a very poor prognosis, with many dying from disturbances of rhythm. The surviving myocytes of these hearts gain Na⁺ , which is positively inotropic because of alterations to Ca²⁺ fluxes mediated by the Na⁺ /Ca²⁺ exchange, but compromises Ca²⁺ -dependent energy metabolism in mitochondria. Uptake of Ca²⁺ into the sarcoplasmic retic

SUBMITTER: MacLeod KT 

PROVIDER: S-EPMC10952717 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature