Chemically Fueled Communication Along a Scaffolded Nanoscale Array of Squaramides.

ABSTRACT: Relaying conformational change over several nanometers is central to the function of allosterically regulated proteins. Replicating this mechanism artificially would provide important communication tools, but requires nanometer-sized molecules that reversibly switch between defined shapes in response to signaling molecules. In this work, 1.8 nm long rigid rod oligo(phenylene-ethynylene)s are scaffolds for switchable multi-squaramide hydrogen-bond relays. Each relay can adopt either a parallel or an antiparallel orientation relative to the scaffold; the preferred orientation is dictated by a director group at one end. An amine director responded to proton signals, with acid-base cycles producing multiple reversible changes in relay orientation that were reported by a terminal NH, which is 1

SUBMITTER: Martinez-Crespo L 

PROVIDER: S-EPMC10952809 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature