Combining electromyography and Raman spectroscopy: optical EMG.

ABSTRACT:

Introduction/aims

Electromyography (EMG) remains a key component of the diagnostic work-up for suspected neuromuscular disease, but it does not provide insight into the molecular composition of muscle which can provide diagnostic information. Raman spectroscopy is an emerging neuromuscular biomarker capable of generating highly specific, molecular fingerprints of tissue. Here, we present "optical EMG," a combination of EMG and Raman spectroscopy, achieved using a single needle.

Methods

An optical EMG needle was created to collect electrophysiological and Raman spectroscopic data during a single insertion. We tested functionality with in vivo recordings in the SOD1^G93A mouse model of amyotrophic lateral sclerosis (ALS), using both transgenic (n = 10) and non-transg

SUBMITTER: Alix JJP 

PROVIDER: S-EPMC10952815 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature