Assessment of the potential of novel and classical opioids to induce respiratory depression in mice.

ABSTRACT:

Background and purpose

Opioid-induced respiratory depression limits the use of μ-opioid receptor agonists in clinical settings and is the main cause of opioid overdose fatalities. The relative potential of different opioid agonists to induce respiratory depression at doses exceeding those producing analgesia is understudied despite its relevance to assessments of opioid safety. Here we evaluated the respiratory depressant and anti-nociceptive effects of three novel opioids and relate these measurements to their in vitro efficacy.

Experimental approach

Respiration was measured in awake, freely moving male CD-1 mice using whole body plethysmography. Anti-nociception was measured using the hot plate test. Morphine, oliceridine and tianeptine were administered intraperitoneally,

SUBMITTER: Hill R 

PROVIDER: S-EPMC10952895 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature