Enabling High Throughput Kinetic Experimentation by Using Flow as a Differential Kinetic Technique.

ABSTRACT: Kinetic data is most commonly collected through the generation of time-series data under either batch or flow conditions. Existing methods to generate kinetic data in flow collect integral data (concentration over time) only. Here, we report a method for the rapid and direct collection of differential kinetic data (direct measurement of rate) in flow by performing a series of instantaneous rate measurements on sequential small-scale reactions. This technique decouples the time required to generate a full kinetic profile from the time required for a reaction to reach completion, enabling high throughput kinetic experimentation. In addition, comparison of kinetic profiles constructed at different residence times allows the robustness, or stability, of homogeneously catalysed reactions to be

SUBMITTER: Lennon G 

PROVIDER: S-EPMC10952970 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature