Replacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk.

ABSTRACT:

Background

Excess sedentary time (ST) is recognized as an important modifiable risk factor for coronary heart disease (CHD). However, whether the associations of genetic susceptibility with CHD incidence can be modified by replacing wearable-device-measured ST with physical activity (PA) is unknown.

Objectives

To examine the associations of wearable-device-measured ST replaced by PA with incident CHD across strata of genetic susceptibility.

Methods

This study included 77,500 White British (57% female) with valid wrist-worn accelerometry and without prevalent CHD/stroke from UK Biobank. Genetic susceptibility to CHD was quantified through weighted polygenic risk scores for CHD based on 300 single-nucleotide polymorphisms. Wrist-worn accelerometer data were used to deri

SUBMITTER: Kim Y 

PROVIDER: S-EPMC10953003 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature