Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Z
PROVIDER: S-EPMC10953043 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Cheng Zhiming Z Thompson Emily J EJ Mendive-Tapia Lorena L Scott Jamie I JI Benson Sam S Kitamura Takanori T Senan-Salinas Ana A Samarakoon Youhani Y Roberts Edward W EW Arias Maykel A MA Pardo Julian J Galvez Eva M EM Vendrell Marc M
Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 20230116 8
Cytotoxic immune cells, including T lymphocytes (CTLs) and natural killer (NK) cells, are essential components of the host response against tumors. CTLs and NK cells secrete granzyme A (GzmA) upon recognition of cancer cells; however, there are very few tools that can detect physiological levels of active GzmA with high spatiotemporal resolution. Herein, we report the rational design of the near-infrared fluorogenic substrates for human GzmA and mouse GzmA. These activity-based probes display ve ...[more]