Comparison of different medical treatments for primary hyperaldosteronism: a systematic review and network meta-analysis.

ABSTRACT:

Background

The effectiveness and side effects between different medical treatments in patients with primary hyperaldosteronism have not been systematically studied.

Objective

To analyze the efficacy between different mineralocorticoid receptor antagonists (MRAs) and epithelial sodium channel (ENaC) inhibitors in a network meta-analysis (NMA) framework, while also evaluating adverse events.

Design

Systematic review and NMA.

Data sources and methods

The systematic review and NMA was reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, MEDLINE, the Cochrane library, and Excerpta Medica database (EMBASE) were searched for randomized controlled trials (RCTs) involving adult patients with primary hyperaldosteron

SUBMITTER: Ho WY 

PROVIDER: S-EPMC10953100 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature