A partial Drp1 knockout improves autophagy flux independent of mitochondrial function.

ABSTRACT:

Background

Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is protective in experimental models of neurological disorders such as Parkinson's disease and Alzheimer's disease. The protective mechanism has been attributed primarily to improved mitochondrial function. However, the observations that Drp1 inhibition reduces protein aggregation in such neurological disorders suggest the involvement of autophagy. To investigate this potential novel protective mechanism of Drp1 inhibition, a model with impaired autophagy without mitochondrial involvement is needed.

Methods

We characterized the effects of manganese (Mn), which causes parkinsonian-like symptoms in humans, on autophagy and mitochondria by performing d

SUBMITTER: Fan RZ 

PROVIDER: S-EPMC10953112 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature