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Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data

ABSTRACT:

SUBMITTER: Fang Q

PROVIDER: S-EPMC10953148 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Differentially expressed circRNAs in recurrent implantation failure

Project description:Our study is designed to demonstrate altered profiles of circRNAs in the luteal-phase endometrium from patients with RIF. Functional studies will be further confirmed. This study will provide new viewpoint for understanding the roles of non-coding RNA for endometrial stromal cells and epithelial cells function, as well as potential etiologic mechanism for RIF.

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Project description:BackgroundRecurrent implantation failure (RIF) is an obstacle in the process of assisted reproductive technology (ART). At present, there is limited research on its pathogenesis, diagnosis, and treatment methods.Methods and resultsIn this study, a series of analytical tools were used to analyze differences in miRNAs, mRNAs, and lncRNAs in the endometrium of patients in a RIF group and a control group. Then the competing endogenous RNA (ceRNA) network was built to describe the relationship between gene regulation in the endometrium of the RIF group. Based on the results of the logistic regression of co-expression miRNAs between serum and endometrial samples, we built a predictive model based on circulating miRNAs.ConclusionThe stability and non-invasiveness of the circular miRNA prediction model provided a new method for diagnosis in RIF patients.

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Project description:Recurrent implantation failure (RIF) is an uncommon, imprecisely defined clinical disorder characterized by failure to achieve pregnancy after repeated embryo transfers. The diverse etiologies and incomplete understanding of RIF provide significant diagnostic and therapeutic challenges to patients and providers. Careful clinical evaluation prior to assisted reproduction can uncover many treatable causes, including thyroid dysfunction, submucosal myomas, and tobacco use. The more-subtle causes often require a more-targeted assessment. Undetected, small polyps or small areas of intrauterine synechiae are relatively common and easily treated contributors to RIF. Molecular and cellular abnormalities pose a greater therapeutic challenge. Putative causes of RIF, including progesterone resistance, shifted window of receptivity, decreased integrin expression, and immunologic disturbances, should be considered in the evaluation of a patient with otherwise unexplained RIF. It may also be true that a more complex and standardized definition of RIF would be helpful in these cases. In this paper, we review the diagnostic and therapeutic approaches to RIF, with emphasis on disorders of endometrial receptivity.

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