Bi₂S₃/Ti₃C₂-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors.

ABSTRACT:

Background

Photodynamic therapy (PDT) efficacy of bismuth sulfide (Bi₂S₃) semiconductor has been severely restricted by its electron-hole pairs (e^--h⁺) separation inefficiency and oxygen (O₂) deficiency in tumors, which greatly hinders reactive oxygen species (ROS) generation and further clinical application of Bi₂S₃ nanoparticles (NPs) in biomedicine.

Results

Herein, novel Bi₂S₃/titanium carbide (Ti₃C₂) two-dimensional nano-heterostructures (NHs) are designed to realize multimode PDT of synchronous O₂ self-supply and ROS generation combined with highly efficient photothermal tumor elimination for hypoxic tumor therapy. Bi₂S₃

SUBMITTER: Jiang H 

PROVIDER: S-EPMC10953153 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature