Sex steroid priming for growth hormone stimulation testing in children and adolescents with short stature: A systematic review.

ABSTRACT:

Objective

Growth hormone stimulation testing (GHST) is used to diagnose growth hormone deficiency (GHD) in children. As sex steroids impact on anterior pituitary function, there is concern around the efficacy of GHST in peripubertal children, where endogenous sex steroid levels are low. Sex steroid priming before GHST is thought to improve test efficacy in these children, however evidence to support its use in clinical practice is limited. In this systematic review, we addressed the following research questions: Does priming increase GH stimulation test efficacy in peripubertal children? Does priming identify those who would benefit most from treatment in terms of final height? Is there evidence for an optimal sex-steroid priming regimen?

Design, patients, measurements

The s

SUBMITTER: Duncan G 

PROVIDER: S-EPMC10953312 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature