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T-cell receptor αβ⁺ double-negative T cells in the kidney are predominantly extravascular and increase in abundance in response to ischemia-reperfusion injury.

ABSTRACT: T-cell receptor⁺ CD4^- CD8^- double-negative (DN) T cells are a population of T cells present in low abundance in blood and lymphoid organs, but enriched in various organs including the kidney. Despite burgeoning interest in these cells, studies examining their abundance in the kidney have reported conflicting results. Here we developed a flow cytometry strategy to clearly segregate DN T cells from other immune cells in the mouse kidney and used it to characterize their phenotype and response in renal ischemia-reperfusion injury (IRI). These experiments revealed that in the healthy kidney, most DN T cells are located within the renal parenchyma and exhibit an effector memory phenotype. In response to IRI, the number of renal DN T cells is unaltered after 24 h

SUBMITTER: Snelgrove SL

PROVIDER: S-EPMC10953373 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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T-cell receptor αβ⁺ double-negative T cells in the kidney are predominantly extravascular and increase in abundance in response to ischemia-reperfusion injury.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

T-cell receptor αβ+ double-negative T cells in the kidney are predominantly extravascular and increase in abundance in response to ischemia-reperfusion injury.

OmicsDI is part of the ELIXIR infrastructure

Tweets

T-cell receptor αβ⁺ double-negative T cells in the kidney are predominantly extravascular and increase in abundance in response to ischemia-reperfusion injury.