DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.

ABSTRACT:

Background

Lateral ventricular volume (LVV) enlargement has been repeatedly linked to schizophrenia; yet, what biological factors shape LVV during early development remain unclear. DNA methylation (DNAm), an essential process for neurodevelopment that is altered in schizophrenia, is a key molecular system of interest.

Methods

In this study, we conducted the first epigenome-wide association study of neonatal DNAm in cord blood with LVV in childhood (measured using T1-weighted brain scans at 10 years), based on data from a large population-based birth cohort, the Generation R Study (N = 840). Employing both probe-level and methylation profile score (MPS) approaches, we further examined whether epigenetic modifications identified at birth in cord blood are: (a) also observed cr

SUBMITTER: Luo M 

PROVIDER: S-EPMC10953396 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature