Biomarkers of asthma relapse and lung function decline in adults with spontaneous asthma remission: A population-based cohort study.

ABSTRACT:

Background

The extent to which biomarkers of asthma activity persist in spontaneous asthma remission and whether such markers are associated with future respiratory outcomes remained unclear. We investigated the association between sub-clinical inflammation in adults with spontaneous asthma remission and future asthma relapse and lung function decline.

Methods

The Tasmanian Longitudinal Health Study is a population-based cohort (n = 8583). Biomarkers of systemic inflammation were measured on participants at age 45, and latent profile analysis was used to identify cytokine profiles. Bronchial hyperresponsiveness (BHR) and nitric oxide products in exhaled breath condensate (EBC NOx) were measured at age 50. Participants with spontaneous asthma remission at ages 45 (n = 466) an

SUBMITTER: Tan DJ 

PROVIDER: S-EPMC10953440 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature