Expanding the Frontier of Linear Drug Design: Cu-Catalyzed C_sp -C_sp ³ -Coupling of Electron-Deficient SF₄ -Alkynes with Alkyl Iodides.

ABSTRACT: Despite the attractive properties of tetrafluorosulfanyl (SF₄ ) compounds in drug discovery, medicinal research on SF₄ molecules is hindered by the scarcity of suitable synthetic methodologies. Drawing inspiration from the well-established Sonogashira cross-coupling of terminal alkynes under Pd-catalysis, it is envisioned that SF₄ -alkynes can serve as effective coupling partners. To overcome the challenges associated with the electron-deficient nature of SF₄ -alkynes and the lability of the SF₄ unit under transition-metal catalysis, an aryl radical mediated C_sp -C_sp ³ cross-coupling reaction is successfully developed under Cu catalysis. This methodology facilitates the coupling of SF₄ -alkyn

SUBMITTER: Narra SR 

PROVIDER: S-EPMC10953538 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature