Cross-population applications of genomics to understand the risk of multifactorial traits involving inflammation and immunity.

ABSTRACT: The interplay between genetic and environmental factors plays a significant role in interindividual variation in immune and inflammatory responses. The availability of high-throughput low-cost genotyping and next-generation sequencing has revolutionized our ability to identify human genetic variation and understand how this varies within and between populations, and the relationship with disease. In this review, we explore the potential of genomics for patient benefit, specifically in the diagnosis, prognosis and treatment of inflammatory and immune-related diseases. We summarize the knowledge arising from genetic and functional genomic approaches, and the opportunity for personalized medicine. The review covers applications in infectious diseases, rare immunodeficiencies and autoimmune di

SUBMITTER: Alamad B 

PROVIDER: S-EPMC10953767 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature