Thrombophilia genetic mutations and their relation to disease severity among patients with COVID-19.

ABSTRACT:

Objectives

Patients with COVID-19 infection appear to develop virus-induced hypercoagulability resulting in numerous thrombotic events. The aim of the present study was to determine the relationship between the thrombophilia genes mutations (prothrombin G20210A, factor V Leiden, and methyltetrahydrofolate reductase (MTHFR)) and the severity of COVID-19 patients.

Design

Prospective cross-sectional study.

Method

One hundred and forty patients (80 adults and 60 children) were included in the current study. They were divided into the severe COVID-19 group and the mild COVID-19 group, with each group comprising 40 adults and 30 children. The patients were assessed for FV R506Q, FV R2H1299R, MTHFR A1298C, MTHFR C677T, and prothrombin gene G20210A polymorphisms. CBC, D-dimer

SUBMITTER: Moness H 

PROVIDER: S-EPMC10954113 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature