Characteristics of cervicovaginal microflora at different cervical maturity during late pregnancy: A nested case-control study.

ABSTRACT:

Objective

The mechanism of cervical ripening in late pregnancy is still unclear. The vaginal microbiome has been reported to correlate with the preterm birth and short cervix in pregnant women. However, the associations between the cervical maturity and the vaginal microbiome are still poorly understood. We aim to analyze the cervicovaginal microflora in women with ripe cervix and in those who are unripe when delivering at term.

Methods

Cervicovaginal swabs were collected between 40 and 41 weeks of gestation from the following 2 different groups of patients: ripe group (n = 25) and unripe group (n = 25). Samples were tested using 16S ribosomal RNA gene high-throughput sequencing and analyzed by bioinformatics platform.

Results

This study highlights the relationship be

SUBMITTER: Chen P 

PROVIDER: S-EPMC10954133 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature