Association of antihypertensives and Parkinson's disease in a primary care population matched for underlying diagnosis.

ABSTRACT:

Purpose

To examine the association of several antihypertensive medication classes with incidence of Parkinson's disease (PD), taking into account possible underlying conditions.

Methods

In a case-control study based on a large primary care database and including 21,981 PD cases and 21,981 non-PD controls matched for age, sex, and possible treatment indications associations with different antihypertensive medication groups, including diuretics, betablockers, calcium channel blockers, angiotensin-converting enzyme inhibitors and angiotensin-II receptor-blockers and PD were examined.

Results

Antihypertensive medications overall were associated with a lower risk of subsequent diagnosis of PD (OR: 0.94, 95% CI 0.90-0.97), with the negative association most significant for

SUBMITTER: Schrag A 

PROVIDER: S-EPMC10954140 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature