Cytokine and T cell responses in post-chikungunya viral arthritis: A cross-sectional study.

ABSTRACT:

Objective

To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy.

Methods

Participants with chikungunya arthritis were recruited from Colombia from 2019-2021. Arthritis disease severity was quantified using the Disease Activity Score-28 and an Arthritis-Flare Questionnaire adapted for chikungunya arthritis. Plasma cytokine concentrations (interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ and tumor necrosis factor (TNF)) were measured using a Meso Scale Diagnostics assay. Peripheral blood T cell subsets were measured using flow cytometry.

Results

Among participants with chikungunya arthritis (N = 158), IL-2 level

SUBMITTER: Chang AY 

PROVIDER: S-EPMC10954186 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature