YAP induces a neonatal-like pro-renewal niche in the adult heart.
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ABSTRACT:
SUBMITTER: Li RG
PROVIDER: S-EPMC10954255 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
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YAP induces a neonatal-like pro-renewal niche in the adult heart.
Li Rich Gang RG Li Xiao X Morikawa Yuka Y Grisanti-Canozo Francisco J FJ Meng Fansen F Tsai Chang-Ru CR Zhao Yi Y Liu Lin L Kim Jong J Xie Bing B Klysik Elzbieta E Liu Shijie S Samee Md Abul Hassan MAH Martin James F JF
Nature cardiovascular research 20240214 3
After myocardial infarction (MI), mammalian hearts do not regenerate, and the microenvironment is disrupted. Hippo signaling loss of function with activation of transcriptional co-factor YAP induces heart renewal and rebuilds the post-MI microenvironment. In this study, we investigated adult renewal-competent mouse hearts expressing an active version of YAP, called YAP5SA, in cardiomyocytes (CMs). Spatial transcriptomics and single-cell RNA sequencing revealed a conserved, renewal-competent CM c ...[more]
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