Early Mortality After the First Dose of COVID-19 Vaccination: A Target Trial Emulation.

ABSTRACT:

Background

Vaccine hesitancy persists alongside concerns about the safety of coronavirus disease 2019 (COVID-19) vaccines. We aimed to examine the effect of COVID-19 vaccination on risk of death among US veterans.

Methods

We conducted a target trial emulation to estimate and compare risk of death up to 60 days under two COVID-19 vaccination strategies: vaccination within 7 days of enrollment versus no vaccination through follow-up. The study cohort included individuals aged ≥18 years enrolled in the Veterans Health Administration system and eligible to receive a COVID-19 vaccination according to guideline recommendations from 1 March 2021 through 1 July 2021. The outcomes of interest included deaths from any cause and excluding a COVID-19 diagnosis. Observations were cloned

SUBMITTER: McConeghy KW 

PROVIDER: S-EPMC10954332 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature