Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance.

ABSTRACT: The coexistence of brown adipocytes with low and high thermogenic activity is a fundamental feature of brown adipose tissue heterogeneity and plasticity. However, the mechanisms that govern thermogenic adipocyte heterogeneity and its significance in obesity and metabolic disease remain poorly understood. Here we show that in male mice, a population of transcription factor jun-B (JunB)-enriched (JunB⁺) adipocytes within the brown adipose tissue exhibits lower thermogenic capacity compared to high-thermogenic adipocytes. The JunB⁺ adipocyte population expands in obesity. Depletion of JunB in adipocytes increases the fraction of adipocytes exhibiting high thermogenic capacity, leading to enhanced basal and cold-induced energy expenditure and protection against diet-induc

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10954369 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature