Radiolabeling Diaminosarcophagine with Cyclotron-Produced Cobalt-55 and [⁵⁵Co]Co-NT-Sarcage as a Proof of Concept in a Murine Xenograft Model.

ABSTRACT: Cobalt-sarcophagine complexes exhibit high kinetic inertness under various stringent conditions, but there is limited literature on radiolabeling and in vivo positron emission tomography (PET) imaging using no carrier added ⁵⁵Co. To fill this gap, this study first investigates the radiolabeling of DiAmSar (DSar) with ⁵⁵Co, followed by stability evaluation in human serum and EDTA, pharmacokinetics in mice, and a direct comparison with [⁵⁵Co]CoCl₂ to assess differences in pharmacokinetics. Furthermore, the radiolabeling process was successfully used to generate the NTSR1-targeted PET agent [⁵⁵Co]Co-NT-Sarcage (a DSar-functionalized SR142948 derivative) and administered to HT29 tumor xenografted mice. The [⁵⁵Co]Co-DSar complex

SUBMITTER: Lin W 

PROVIDER: S-EPMC10954389 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature