Selective neural inhibition via photobiomodulation alleviates behavioral hypersensitivity associated with small sensory fiber activation.

ABSTRACT:

Objective

Photobiomodulation at higher irradiances has great potential as a pain-alleviating method that selectively inhibits small diameter nerve fibers and corresponding sensory experiences, such as nociception and heat sensation. The longevity and magnitude of these effects as a function of laser irradiation parameters at the nerve was explored.

Methods

In a rodent chronic pain model (spared nerve injury-SNI), light was applied directly at the sural nerve with four delivery schemes: two irradiance levels (7.64 and 2.55 W/cm² ) for two durations each, corresponding to either 4.8 or 14.4 J total energy, and the effect on sensory hypersensitivities was evaluated.

Results

At emitter irradiances of 7.64 W/cm² (for 240 s), 2.55 W/cm² (for

SUBMITTER: Buzza A 

PROVIDER: S-EPMC10954407 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature