Role of the CCL5 and Its Receptor, CCR5, in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage.

ABSTRACT:

Background

Aldosterone has been described to initiate cardiovascular diseases by triggering exacerbated sterile vascular inflammation. The functions of CCL5 (C-C motif chemokine ligand 5) and its receptor CCR5 (C-C motif chemokine receptor 5) are well known in infectious diseases, their contributions to aldosterone-induced vascular injury and hypertension remain unknown.

Methods

We analyzed the vascular profile, blood pressure, and renal damage in wild-type (CCR5^+/+) and CCR5 knockout (CCR5^-/-) mice treated with aldosterone (600 µg/kg per day for 14 days) while receiving 1% saline to drink. Vascular function was analyzed in aorta and mesenteric arteries, blood pressure was measured by telemetry and renal injury and inflammation were analyzed via histolo

SUBMITTER: Costa RM 

PROVIDER: S-EPMC10954408 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature