Acute decompensation of cirrhosis versus acute-on-chronic liver failure: What are the clinical implications?

ABSTRACT: It is essential to identify the subgroup of patients who experience poorer outcomes in order to adapt clinical management effectively. In the context of liver disease, the earlier the identification occurs, the greater the range of therapeutic options that can be offered to patients. In the past, patients with acute decompensation (AD) of chronic liver disease were treated as a homogeneous group, with emphasis on identifying those at the highest risk of death. In the last 15 years, a differentiation has emerged between acute-on-chronic liver failure syndrome (ACLF) and AD, primarily due to indications that the latter is linked to a less favorable short-term prognosis. Nevertheless, the definition of ACLF varies among the different knowledge societies, making it challenging to assess its tr

SUBMITTER: Xu M 

PROVIDER: S-EPMC10954432 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature