Translation variation across genetic backgrounds reveals a post-transcriptional buffering signature in yeast.

ABSTRACT: Gene expression is known to vary among individuals, and this variability can impact the phenotypic diversity observed in natural populations. While the transcriptome and proteome have been extensively studied, little is known about the translation process itself. Here, we therefore performed ribosome and transcriptomic profiling on a genetically and ecologically diverse set of natural isolates of the Saccharomyces cerevisiae yeast. Interestingly, we found that the Euclidean distances between each profile and the expression fold changes in each pairwise isolate comparison were higher at the transcriptomic level. This observation clearly indicates that the transcriptional variation observed in the different isolates is buffered through a phenomenon known as post-transcriptional buffering at

SUBMITTER: Teyssonniere EM 

PROVIDER: S-EPMC10954453 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature