Smoking blunts sertraline response in depression: A prospective observational cohort study.

ABSTRACT:

Background

Smoking is common in patients of depression and is known to affect response to antidepressants. This study was undertaken to evaluate the effect of smoking on the antidepressant effect of sertraline.

Method

Patients with depression were divided into smoker and nonsmoker cohorts and followed up for 8 weeks. Serum sertraline levels were estimated using the high-performance liquid chromatography system. Response to treatment was evaluated with the Hamilton Depression Rating Scale (HAM-D).

Results

Serum sertraline levels did not differ between smokers and nonsmokers at 4 and 8 weeks. Nonsmokers responded better to sertraline than smokers after 8 weeks. Adverse drug reaction profile did not vary between the two groups and was not impacted by serum sertraline lev

SUBMITTER: Mohan P 

PROVIDER: S-EPMC10954491 | biostudies-literature | 2024 Mar-Apr

REPOSITORIES: biostudies-literature