An atlas of epithelial cell states and plasticity in lung adenocarcinoma.

ABSTRACT: Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies¹. Here we studied 246,102 single epithelial cells from 16 early-stage LUADs and 47 matched normal lung samples. Epithelial cells comprised diverse normal and cancer cell states, and diversity among cancer cells was strongly linked to LUAD-specific oncogenic drivers. KRAS mutant cancer cells showed distinct transcriptional features, reduced differentiation and low levels of aneuploidy. Non-malignant areas surrounding human LUAD samples were enriched with alveolar intermediate cells that displayed elevated KRT8 expression (termed KRT8⁺ alveolar intermediate cells (KACs) here), reduced differentiation, increased plasticity and driver

SUBMITTER: Han G 

PROVIDER: S-EPMC10954546 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature