Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both?

ABSTRACT: Regulatory T cells (Tregs) are a specialized subgroup of T-cell lymphocytes that is crucial for maintaining immune homeostasis and preventing excessive immune responses. Depending on their differentiation route, Tregs can be subdivided into thymically derived Tregs (tTregs) and peripherally induced Tregs (pTregs), which originate from conventional T cells after extrathymic differentiation at peripheral sites. Although the regulatory attributes of tTregs and pTregs partially overlap, their modes of action, protein expression profiles, and functional stability exhibit specific characteristics unique to each subset. Over the last few years, our knowledge of Treg differentiation, maturation, plasticity, and correlations between their phenotypes and functions has increased. Genetic and function

SUBMITTER: Hardtke-Wolenski M 

PROVIDER: S-EPMC10954601 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature