A Hybrid Electrospun-Extruded Polydioxanone Suture for Tendon Tissue Regeneration.

ABSTRACT: Many surgical tendon repairs fail despite advances in surgical materials and techniques. Tendon repair failure can be partially attributed to the tendon's poor intrinsic healing capacity and the repurposing of sutures from other clinical applications. Electrospun materials show promise as a biological scaffold to support endogenous tendon repair, but their relatively low tensile strength has limited their clinical translation. It is hypothesized that combining electrospun fibers with a material with increased tensile strength may improve the suture's mechanical properties while retaining biophysical cues necessary to encourage cell-mediated repair. This article describes the production of a hybrid electrospun-extruded suture with a sheath of submicron electrospun fibers and a core of melt-

SUBMITTER: Abhari RE 

PROVIDER: S-EPMC10954604 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature